Research

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Research

What is Langerhans Cell Histiocytosis (LCH)?

What is Langerhans Cell Histiocytosis (LCH)?

Langerhans cell histiocytosis (LCH) is a rare disorder in which the body produces an overabundance of Langerhans cells. These cells, which are also known as histiocytes, are a type of white blood cell that helps the immune system fight off infections. LCH causes too many of these cells to form, ultimately resulting in a buildup in the body. This accumulation of cells then damages organs, forms tumors, and otherwise disrupts normal tissue functions. According to the Histiocytosis Association,...

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What Is an Independent Investigator Grant?

What Is an Independent Investigator Grant?

Independent Investigator Grants are awarded to principal investigators. Let’s begin by explaining the role of a principal investigator. Principal investigators are typically faculty members (e.g., professor, associate professor, assistant professor) who lead a research lab as an expert in their field. As the lab leader, they are responsible for developing the research agenda, designing research projects, securing funding (often through grants like Rally Foundation for Childhood Cancer...

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What is Ependymoma?

What is Ependymoma?

Ependymoma is a tumor that appears most often in the brain and sometimes in the spinal cord. It is a type of glioma, meaning it starts in the support cells of the brain. This cancer occurs more frequently in children—accounting for 5-10% of all pediatric brain tumors—but it can also affect adults. Common pediatric subtypes include classic ependymoma, a tumor that most commonly appears in the brain, and anaplastic ependymoma, which tends to spread and has a high chance of recurrence. Each type...

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What Is a Postdoctoral and Clinical Research Fellow Grant?

What Is a Postdoctoral and Clinical Research Fellow Grant?

Before we get to that, let’s first address the difference between a postdoctoral fellow and a clinical research fellow. It can definitely be confusing. A postdoctoral fellow, also called a postdoc, is someone who completed a Ph.D. program and is now conducting research under the guidance of a principal investigator (mentor) with the goal of one day having their own lab. A clinical research fellow is someone who graduated from medical school and completed their residency. The fellowship...

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What is Lymphoma?

What is Lymphoma?

Lymphoma is a cancer of the body’s lymphatic (lymph) system which is essential to the immune system. The lymphatic system is made up of a type of white blood cells also known as lymphocytes which flow throughout the whole body. These lymphocytes fight infections throughout the body, so when cancerous cells begin to grow they can quickly spread through the entire lymph system. This then makes it difficult for the immune system to work properly. Early symptoms of lymphomas usually begin with a...

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What is Chronic Myeloid Leukemia (CML)?

What is Chronic Myeloid Leukemia (CML)?

Chronic myeloid leukemia (CML) is a type of blood cancer that causes an overproduction of white blood cells. These cells grow abnormally and can build up in the blood and bone marrow, leaving less room for healthy white and red blood cells as well as platelets. CML is commonly associated with a genetic mutation called the Philadelphia chromosome. While CML is very rare in children, with about 150 pediatric cases in the U.S. each year, it’s often more aggressive in kids than it is in adults....

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