Success Stories

New RNA Therapies for Glioblastoma from Small Phase 1 Study

New RNA Therapies for Glioblastoma from Small Phase 1 Study

Glioblastoma (GBM) in children and adults is a deadly brain tumor with a poor prognosis. Current treatment includes surgery to remove as much of the tumor as possible, followed by radiation and chemotherapy. Unfortunately, most patients still experience tumor growth despite the treatment and have a median survival of less than two years.  Immunotherapy has shown success in the treatment of other types of tumors, but that success has been elusive with malignant brain tumors, such as GBM. However, new ribonucleic acid (RNA) based immunotherapy is showing promise in treatment for GBM. Rally-funded researcher Elias Sayour, MD, PhD, and his team at the University of Florida recently published exciting discoveries focusing on the utilization of RNA dendritic cell (DC) vaccines and RNA nanoparticle therapies in the treatment of GBM. RNA-based therapies offer clear advantages over other...

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AML Treatment Developments

AML Treatment Developments

Rally Foundation for Childhood Cancer Research is excited to announce new developments in the treatment of childhood acute myeloid leukemia (AML) emerging from research in the Meshinchi laboratory at the Fred Hutchinson Cancer Research Center (Fred Hutch) in Seattle. Immunotherapy is a type of treatment that harnesses the immune system to kill cancer cells.  To avoid toxicity and unpleasant side effects of treatment, researchers search for molecules or a “target” on the surface of cancer cells that do not exist on normal cells, so only the targeted cancer cells are attacked by the immune system. Such immunotherapies, including Chimeric Antigen Receptor (CAR) T-cell immunotherapy, have been successful in the treatment of acute lymphoblastic leukemia (ALL). Identification of such targets for AML has been more challenging because many of the targets found on AML cancer cells are also...

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The New England Journal of Medicine

The New England Journal of Medicine

Chills ran up and down my arms when I opened the link that Rally-funded researcher Dr. Gregory Friedman sent. I was staring at the New England Journal of Medicine logo, an article about Dr. Friedman’s brain cancer research and an acknowledgement to Rally for our support. “As a young investigator in 2013, I received my first grant directly supporting my lab research from Rally. The support enabled us to obtain the critical preclinical data needed for FDA approval to conduct the first pediatric trial of the therapy in recurrent high-grade gliomas,” shared Dr. Friedman. This week Dr. Friedman’s research was published in the New England Journal of Medicine, one of the most prestigious—if not the most prestigious—medical journals in the world. I often say at Rally we like to fund early, aren’t afraid of outside the box ideas and as long as the research is making progress, we will stick with...

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How Rally’s Grant Helped Rally Researcher Dr. Michael Kinnaman: Part 2

How Rally’s Grant Helped Rally Researcher Dr. Michael Kinnaman: Part 2

Rally Researcher, Medical Advisory Board member and pediatric oncologist Dr. Michael Kinnaman is the recipient of Rally’s Postdoctoral and Clinical Research Fellow Grant and most recently was awarded a 2020 Young Investigator Grant. In part two of this two-part series, Dr. Kinnaman reveals how our grant has helped fund his research project on characterizing osteosarcoma tumor cells that are resistant to our current therapy with the end goal of discovering new treatment strategies that are specifically targeted towards these resistant tumor cells. Read part one here.   Dr. Kinnaman Seeks to Understand the Complexities of Osteosarcoma One of the first patients I saw as a fellow at MSK Kids, Memorial Sloan Kettering’s Pediatric program, was a 12-year-old boy with newly diagnosed osteosarcoma of his right thigh bone. Osteosarcoma is the most common malignant bone tumor in children and...

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Newly Elected COG Chair Dr. Douglas Hawkins Shares His ‘North Star’

Newly Elected COG Chair Dr. Douglas Hawkins Shares His ‘North Star’

Rally was pleased when it was announced that the newly elected chair of the Children’s Oncology Group (COG) was going to be Dr. Doug Hawkins, a Rally-funded Researcher who has served for the past nine years on the Rally Medical Advisory Board and received funding for early phase trials and biologic specimen collection at Seattle Children’s Hospital (SCH). Dr. Hawkins is also the Division Chief of Hematology-Oncology and the Associate Director of the Center for Clinical and Translational Research at SCH. He transitioned into his role as chair this month, taking the reins from fellow Rally-funded Researcher, Medical Advisory Board member and current COG chair, Dr. Peter Adamson. At Rally, we work endlessly to uphold our mission of funding childhood cancer research in hopes of finding better treatments with fewer long-term side effects and ultimately, a cure. We believe that every child...

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2019 Rally Foundation Year In Review

2019 Rally Foundation Year In Review

Thank you for caring about kids fighting cancer, and thank you for giving toRally For Their Future. Rally Kid Brecklynn, who is six years old and has fought cancer twice, put it best: She said that all she wanted was to be a “plain girl,” meaning she just wanted to be a normal little girl playing dress up and having tea parties—not getting needle pokes and chemo cocktails. Your financial gift allows kids like Brecklynn, who are fighting cancer, to have the chance to be a “plain kid.” Your gift truly gives hope For Their Future. Cancer takes so much from these precious kids. The drugs used to treat them are harsh, outdated and come with a plethora of harmful side effects. Rally Kid Keren endured painful treatments. Not only did she lose her hair and a year of school, but she also lost her leg. Kids with cancer need you. We need you. We cannot do this without you. We are philanthropic...

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Success Stories

New RNA Therapies for Glioblastoma from Small Phase 1 Study

New RNA Therapies for Glioblastoma from Small Phase 1 Study

Glioblastoma (GBM) in children and adults is a deadly brain tumor with a poor prognosis. Current treatment includes surgery to remove as much of the tumor as possible, followed by radiation and chemotherapy. Unfortunately, most patients still experience tumor growth despite the treatment and have a median survival of less than two years.  Immunotherapy has shown success in the treatment of other types of tumors, but that success has been elusive with malignant brain tumors, such as GBM....

read more
AML Treatment Developments

AML Treatment Developments

Rally Foundation for Childhood Cancer Research is excited to announce new developments in the treatment of childhood acute myeloid leukemia (AML) emerging from research in the Meshinchi laboratory at the Fred Hutchinson Cancer Research Center (Fred Hutch) in Seattle. Immunotherapy is a type of treatment that harnesses the immune system to kill cancer cells.  To avoid toxicity and unpleasant side effects of treatment, researchers search for molecules or a “target” on the surface of cancer cells...

read more
The New England Journal of Medicine

The New England Journal of Medicine

Chills ran up and down my arms when I opened the link that Rally-funded researcher Dr. Gregory Friedman sent. I was staring at the New England Journal of Medicine logo, an article about Dr. Friedman’s brain cancer research and an acknowledgement to Rally for our support. “As a young investigator in 2013, I received my first grant directly supporting my lab research from Rally. The support enabled us to obtain the critical preclinical data needed for FDA approval to conduct the first pediatric...

read more
How Rally’s Grant Helped Rally Researcher Dr. Michael Kinnaman: Part 2

How Rally’s Grant Helped Rally Researcher Dr. Michael Kinnaman: Part 2

Rally Researcher, Medical Advisory Board member and pediatric oncologist Dr. Michael Kinnaman is the recipient of Rally’s Postdoctoral and Clinical Research Fellow Grant and most recently was awarded a 2020 Young Investigator Grant. In part two of this two-part series, Dr. Kinnaman reveals how our grant has helped fund his research project on characterizing osteosarcoma tumor cells that are resistant to our current therapy with the end goal of discovering new treatment strategies that are...

read more
Newly Elected COG Chair Dr. Douglas Hawkins Shares His ‘North Star’

Newly Elected COG Chair Dr. Douglas Hawkins Shares His ‘North Star’

Rally was pleased when it was announced that the newly elected chair of the Children’s Oncology Group (COG) was going to be Dr. Doug Hawkins, a Rally-funded Researcher who has served for the past nine years on the Rally Medical Advisory Board and received funding for early phase trials and biologic specimen collection at Seattle Children’s Hospital (SCH). Dr. Hawkins is also the Division Chief of Hematology-Oncology and the Associate Director of the Center for Clinical and Translational...

read more
2019 Rally Foundation Year In Review

2019 Rally Foundation Year In Review

Thank you for caring about kids fighting cancer, and thank you for giving toRally For Their Future. Rally Kid Brecklynn, who is six years old and has fought cancer twice, put it best: She said that all she wanted was to be a “plain girl,” meaning she just wanted to be a normal little girl playing dress up and having tea parties—not getting needle pokes and chemo cocktails. Your financial gift allows kids like Brecklynn, who are fighting cancer, to have the chance to be a “plain kid.” Your gift...

read more

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