Osteosarcoma (OS) is a type of cancer that begins in the cells that form bones, and mainly affects teenagers and young adults. In metastatic osteosarcoma, the cancer spreads from the primary bone site to another location, most often the lungs. It can also spread to other bones, the brain or other organs. Currently there are no curative treatments for metastatic osteosarcoma. We urgently need to develop new therapies. To better understand a disease, it is common for tumor research studies to use orthotopic implantation. This method grafts tumor tissue where the disease begins in a mouse model. For osteosarcoma studies that would be in a bone allowing researchers to examine cancer progression more accurately and identify potential drug combinations more reliably. Rally-funded researcher Lindsay Jones Talbot, MD, is a pediatric surgeon, researcher, and instructor at St. Jude Children’s...
