What is Diffuse Intrinsic Pontine Glioma (DIPG)?
Diffuse intrinsic pontine glioma (DIPG) is a brain tumor found in a part of the brain stem—above the back of the neck and connected to the spine—called the pons. The pons is a vital part of the brain, controlling critical bodily functions like breathing, swallowing, blood pressure, heart rate, eyesight and balance. DIPG occurs almost exclusively in children; most often between the ages of four and 11. DIPG accounts for roughly 10-15% of all brain tumors in children. These tumors—called gliomas because they grow from glial cells—permeate healthy brain tissue and cause severe symptoms. DIPG is classified into four stages, with Grade III and IV being the most aggressive. DIPG SIGNS AND SYMPTOMS Children with DIPG typically experience double vision, loss of balance and clumsiness, weakness in the arm and legs, nausea and vomiting, headaches (especially in the morning) and difficulty with...
What is a Glioma?
“Glioma” is a general term for a group of tumors that begin in glial cells—the supporting cells of the brain. Gliomas are classified based on their location and by the type of glial cell—astrocytes, oligodendrocytes or ependymocytes—from which they arise. Thus, many different types of brain tumors are classified as gliomas, like astrocytomas, oligodendrogliomas, ependymomas, brain stem gliomas and glioblastomas. About half of all pediatric brain and spinal cord tumors are gliomas. Gliomas are the most common group of brain tumors in both children and adults. “There are studies that definitely show that while pediatric high-grade gliomas share certain features with adult gliomas, they are also biologically distinct from adult high-grade gliomas,” said Rally-funded Researcher Renee Read, Ph.D., Assistant Professor, Department of Pharmacology and Chemical Biology and Department of...
What is Acute Lymphoblastic Leukemia (ALL)?
Acute lymphoblastic leukemia, also called acute lymphocytic leukemia, or ALL for short, is a type of blood cancer that causes bone marrow to overproduce a type of white blood cells called lymphoblasts. ALL is the most common type of cancer that affects kids, accounting for roughly 30% of all cases of childhood cancer. Lymphoblasts are immature white blood cells that are responsible for identifying and destroying foreign invaders like bacteria and viruses. When someone has ALL, the bone marrow produces too many lymphoblasts that do not mature properly. These immature lymphoblasts prevent normal lymphocytes from forming and are simultaneously unable to fight infections in the body. Signs and Symptoms of Acute Lymphoblastic Leukemia The fact that ALL affects the body’s defense system means that the disease will likely cause a lot of problems for patients before being diagnosed. These...
What is Retinoblastoma?
In simple terms, retinoblastoma is an eye cancer that develops in the immature cells of the retina. Though it is rare—with approximately 300 children diagnosed in the U.S. each year—it is the most common eye cancer in children. This malignant intraocular cancer rarely occurs in adults. Retinoblastoma can occur in one or both eyes and is caused by genetic mutations in the nerve cells of the retina. The retina is comprised of nerve tissue and is the part of the eye that’s responsible for sensing light and signaling the brain through the optic nerve to interpret that light as images. The risk for this type of cancer can be hereditary if one or both parents carry a mutated gene. Hereditary retinoblastoma tends to present in both eyes and often appears at an earlier age. Retinoblastoma is typically found in children under age five, with the average age of diagnosis being 18 months old. Boys...
What is Wilms Tumor?
Wilms tumor is a type of kidney cancer that primarily develops in children around the ages of three and four. It’s the most common type of kidney cancer found in kids. Approximately 9 out of 10 kidney cancers in children are Wilms tumors, sometimes known as nephroblastoma. There are two types of Wilms tumors that are classified by their histology, or how they look microscopically: favorable histology and anaplastic histology. A Wilms tumor with favorable histology means that, while the tumor isn’t normal, the cells aren’t too large or distorted and the patient will typically have a better prognosis. Anaplastic histology means that the cancer cells vary greatly and have large, distorted nuclei. This is called anaplasia and is harder to treat than tumors with favorable histology. Signs and Symptoms of Wilms Tumor Common signs and symptoms of Wilms tumor are masses in the abdomen and...
Cancer in Teens and Young Adults
Childhood cancer is a big problem. In the U.S. alone, 46 children are diagnosed with cancer every school day. But it doesn’t just affect school-age children -- babies, teens, and young adults can get childhood cancer, too. In the last 20 years, thanks to research, many more young children and older adults are surviving their cancers. But that’s not the case for teens and young adults. Teens and young adults are unique. Their cancers are different, their bodies are different, and they face different challenges than their younger and older counterparts. Here’s a closer look at how cancer affects this age group. Common Cancers in Teens and Young Adults The most common cancers for teens and young adults up to age 25 are blood cancers (leukemia and lymphoma), thyroid cancer, and testicular cancer. Other common cancers in teens and young adults include: Brain tumors Bone cancer Cervical...
What is Diffuse Intrinsic Pontine Glioma (DIPG)?
Diffuse intrinsic pontine glioma (DIPG) is a brain tumor found in a part of the brain stem—above the back of the neck and connected to the spine—called the pons. The pons is a vital part of the brain, controlling critical bodily functions like breathing, swallowing, blood pressure, heart rate, eyesight and balance. DIPG occurs almost exclusively in children; most often between the ages of four and 11. DIPG accounts for roughly 10-15% of all brain tumors in children. These tumors—called gliomas...
What is a Glioma?
“Glioma” is a general term for a group of tumors that begin in glial cells—the supporting cells of the brain. Gliomas are classified based on their location and by the type of glial cell—astrocytes, oligodendrocytes or ependymocytes—from which they arise. Thus, many different types of brain tumors are classified as gliomas, like astrocytomas, oligodendrogliomas, ependymomas, brain stem gliomas and glioblastomas. About half of all pediatric brain and spinal cord tumors are gliomas. Gliomas are...
What is Acute Lymphoblastic Leukemia (ALL)?
Acute lymphoblastic leukemia, also called acute lymphocytic leukemia, or ALL for short, is a type of blood cancer that causes bone marrow to overproduce a type of white blood cells called lymphoblasts. ALL is the most common type of cancer that affects kids, accounting for roughly 30% of all cases of childhood cancer. Lymphoblasts are immature white blood cells that are responsible for identifying and destroying foreign invaders like bacteria and viruses. When someone has ALL, the bone marrow...
What is Retinoblastoma?
In simple terms, retinoblastoma is an eye cancer that develops in the immature cells of the retina. Though it is rare—with approximately 300 children diagnosed in the U.S. each year—it is the most common eye cancer in children. This malignant intraocular cancer rarely occurs in adults. Retinoblastoma can occur in one or both eyes and is caused by genetic mutations in the nerve cells of the retina. The retina is comprised of nerve tissue and is the part of the eye that’s responsible for sensing...
What is Wilms Tumor?
Wilms tumor is a type of kidney cancer that primarily develops in children around the ages of three and four. It’s the most common type of kidney cancer found in kids. Approximately 9 out of 10 kidney cancers in children are Wilms tumors, sometimes known as nephroblastoma. There are two types of Wilms tumors that are classified by their histology, or how they look microscopically: favorable histology and anaplastic histology. A Wilms tumor with favorable histology means that, while the tumor...
Cancer in Teens and Young Adults
Childhood cancer is a big problem. In the U.S. alone, 46 children are diagnosed with cancer every school day. But it doesn’t just affect school-age children -- babies, teens, and young adults can get childhood cancer, too. In the last 20 years, thanks to research, many more young children and older adults are surviving their cancers. But that’s not the case for teens and young adults. Teens and young adults are unique. Their cancers are different, their bodies are different, and they face...