Cigall Kadoch, PHD

Dana-Farber Cancer Institute; Boston, MA – Assistant Professor, Pediatric Oncology

Cigall Kadoch, PhD completed her graduate studies at the Stanford University School of Medicine and Howard Hughes Medical Institute in the Laboratory of Dr. Gerald Crabtree. Here, Dr. Kadoch worked to identify and characterize novel components of a chromatin remodeling complex, among them, SS18, which is translocated in synovial sarcoma (t(X;18)), resulting in the hallmark SS18-SSX oncogenic fusion protein. Through a series of biochemical and mechanistic investigations, Kadoch uncovered a mechanism of oncogenesis driven by SS18-SSX mediated perturbation to mSWI/SNF (BAF) chromatin remodeling complexes.