Edward V. Prochownik, MD

UPMC Children’s Hospital of Pittsburgh – Director of Oncology Research

University of Pittsburgh School of Medicine – Professor of Molecular Genetics and Biochemistry

Dr. Prochownik is interested in cancers resulting from the de-regulated expression of the c-Myc oncoprotein. He is using animal models of pediatric and adult liver cancer (hepatoblastoma and hepatocellular carcinoma) to ascertain the molecular, biochemical, and metabolic changes that accompany tumor progression, regression, and recurrence. For over 30 years, Dr. Prochownik‘s laboratory has been engaged in continuous studies of the c-Myc (Myc) oncoprotein and its role in cancer. They were the first to demonstrate that Myc deregulation blocks terminal differentiation of hematopoietic cells, a finding that has since been extended to multiple other systems and is a central aspect of Myc-mediated transformation

Dr. Prochownik earned his PhD in Pathology/Virology from the University of Chicago, and MD from the University of Chicago-Pritzker School of Medicine. He was an Intern and Junior Assistant Resident in Pediatrics at Boston’s Children’s Hospital, and a Clinical and Research Fellow in Pediatric Hematology-Oncology at Boston Children’s Hospital and Dana Farber Cancer Institute-Harvard Medical School.