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Dr. Kristopher Bosse is an Assistant Professor in the Division of Oncology and the Department of Pediatrics at the Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn). Dr. Bosse is a physician-scientist focused on the pediatric cancer neuroblastoma. After starting his research career focused on the physical sciences, he was awarded a prestigious Howard Hughes Medical Institute Training Award during medical school to investigate the functional mechanisms underlying several neuroblastoma predisposition loci discovered via a genome-wide association study approach. Dr. Bosse remains interested in defining how both common and rare genomic variation predisposes to pediatric cancers, particularly in describing the role of the BARD1 gene. Dr. Bosse is also currently part of a large collaborative effort funded by a St. Baldrick’s Foundation-Stand Up to Cancer grant to bring the fields of genomics and immunology together to develop new immunotherapies to combat childhood cancers. The Bosse laboratory is currently using an integrated genomic and functional approach to identify and validate novel cell surface molecules for immunotherapeutic targeting in high-risk neuroblastoma and several related pediatric cancers. These efforts include a comprehensive research program focused on developing glypican 2 (GPC2)-directed antibody-drug conjugates and chimeric antigen receptor (CAR) T cell therapies, the latter recently leading to the opening of a first-in-human Phase 1 clinical trial for children with neuroblastoma.
Dr. Bosse graduated summa cum laude with honors from Bowdoin College and he completed his medical degree and training at Penn and CHOP.